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4. Delirium, dementia, and amnestic and other cognitive disorders

Any physiologic condition or pathophysiologic process that is capable of destroying or altering brain tissue impairs cerebral functioning. Regardless of the physical cause, the symptoms are typically cognitive impairment, behavioral dysfunctions, and personality changes. The most common symptomatology noted from the DSM-IV category is delirium, dementia, and amnestic disorders. (For further information, see Major Cognitive Disorders, page 58.)

Delirium
DSM-IV CATEGORIES
293.0 Delirium due to ... (indicate the general medical condition)
__._ Substance intoxication delirium (refer to substance-related disorders for substance-specific codes)
__._ Substance withdrawal delirium (refer to substance-related disorders for substance-specific codes)
__._ Delirium due to multiple etiologies (code each of the specific etiologies)
780.09 Delirium NOS

With this disorder, a person exhibits a disturbance in consciousness and a change in cognition unexplainable by a prior or currently developing dementia. The disturbance occurs over a short period and changes its presentation during the day. Typically, the delirium resolves in hours or days unless a concurrent dementia is present. The health examination and laboratory work indicate that the delirium is a result of a physiologic medical condition. substance intoxication or withdrawal, medication use, toxic exposure, or a combination of these factors. The sooner the underlying problem is identified, the faster the symptoms can be corrected and the delirium resolved. Delirium can affect all cllients, but it's most prevalent in people over age 65 who are hosci-talized for a general medical or surgical problem.

MAJOR COGNITIVE DISORDERS
TYPE OF DISORDER
COMMON SYMPTOMS
Delirium disorder
  • Lack of response to environmental stimuli
  • Disorientation
  • Disorganized thinking
  • Rambling or incoherent speech
  • Illusions or hallucinations
  • Insomnia or daytime sleepiness
  • Impaired psychomotor skills
Dementia disorder
  • Short- and long-term memory impairment
  • Impaired abstract thinking
  • Impaired judgment
  • Impaired social and occupational functioning
  • Changes in personality
Amnestic disorder
  • Memory impairment (due to a medical problem or persistent use of a drug)
  • Impairment in ability to learn new information
  • Inability to recall past situations
  • Memory disturbance not occurring during a delirium or a dementia
  • Impaired social and occupational functioning compared with prior level of functioning
  • Confabulation (gaps in memory filled in with fabrications)
  • Apathy
  • Shallow affect

Symptomatically, the client presents with impairment in attention demonstrated by being easily distracted and unable to rc-cus or shift attention from one topic to the another. The probler". may be so serious that the person can't be engaged in a conversation. In addition, there is a major change in cognition manifested by disorientation, especially to time and place; memory impairment particularly recent memory; and language disturbance, primarily the inability to write and name objects. Speech may be rambling and incoherent as the client moves quickly from one topic to another. Sensory disturbances, such as misinterpretations, illusions, or even hallucinations, can occur.

Delirium is often accompanied by disturbed psychomotor behavior, such as sudden movements, hyperactivity, restlessness, and picking at clothing. Psychomotor activity may vary from the hyperactive extreme to a slowed, lethargic state during the course of a day. The client also shows unpredictable, changing emotional states such as apathy, anxiety, depression, irritability, anger, fear, and euphoria. A person who displays these symptoms is at risk for self-injury and may also hurt others because of overwhelming fear or an altered mental state.

The neurobiological mechanisms underlying the development of delirium aren't well understood. Common pathological causes of delirium include drug intoxication and withdrawal, poisoning, systemic and intracranial infections, metabolic disorders, neurologic disorders, brain lesions, and severe physical injury. Psycho-social stressors, such as abrupt life changes, as well as sensory overload or deprivation and sleep deprivation can also provoke delirium. Some commonly prescribed medications (antiarrhythmics, antihistamines, antihypertensives, psychotro-pics, anticholinergics, and analgesics) can also induce delirium.

SUBSTANCE-INDUCED DELIRIUM

One of the main types of delirium is substance-induced delirium When the delirium occurs during substance intoxication, it's called substance intoxication delirium: if it occurs during substance withdrawal, it's diagnosed as substance withdrawal delirium. The delirium manifested by substance intoxication occurs after large amounts of specific drugs, such as cocaine, alcohol, and hallucinogens have been taken. The episode of delirium resolves as the intoxication ends. With substance withdrawal delirium, the delirium occurs after a reduction in or cessation of substance use and tissue and fluid levels of the substance decrease. The duration of the delirium depends on the half-life of the substance involved. Usually, substance withdrawal delirium lasts for several hours, but it may continue for up to 4 weeks.

COMMUNICATION STRATEGIES

NURSING DIAGNOSIS: RISK FOR INJURY
Probable CausesDefining Characteristics
Genetic predisposition for substance abuse disorderAgitated behavior
Metabolic or neurologic changes associated with substance abuseDysfunctional behaviors
Delusions or hallucinationsBalance difficulties or falling
Intoxication or withdrawal from use of psychoactive substanceFailure to observe usual safety rules, such as stopping at a street corner before crossing and testing water temperature before bathing
Inability to assess reality and potential dangers in the environmentInappropriate handling of items such as glass and machinery

Long-Term Goal
The client will maintain a safe and optimal level of functioning.

Short-Term Goal #1: The client will have decreased periods of confusion and will maintain contact with reality.

Interventions and Rationales

Short-Term Goal #2: The client will interact appropriately with staff on a daily basis.

Interventions and Rationales

NURSING DIAGNOSIS: SENSORY/PERCEPTUAL ALTERATIONS, INCLUDING VISUAL AND AUDITORY HALLUCINATIONS
Probable CausesDefining Characteristics
  • Alteration in neurotransmitters serotonin, and dopamine levels associated with substance abuse
  • Seizure disorder
  • Cerebral hypoxia
  • Intoxication from use of a psychoactive substance
  • Severe anxiety
  • Disorientation
  • Cognitive impairment
  • Irritability
  • Aggressive behavior
  • Inability to problem solve or make decisions

Long-Term Goal
The client will learn to function normally by managing the stress associated with delusions, abnormal sensations, and hallucinations.

Short-Term Goal #1: The client will develop methods to manage the stress associated with delusional thinking and misperceptions.

Interventions and Rationales

Short-Term Goal #2: The client will reduce bizarre or inappropriate behavior and relate appropriately to the everyday environment.

Interventions and Rationales

THERAPIES

A client with delirium requires prompt medical intervention. Once the client is stabilized, some limited individual therapy and group therapy may be useful.

Medical/Biological Interventions
Individual Therapy
Group Therapy

Only when delirium has subsided can a client be in a group, initiate contact, and acknowledge other people.

MEDICATIONS

Medications are used to manage the underlying causes of the client's delirium, current health condition, and symptoms associated with an agitated state.

MEDICATIONS USED FOR DETOXIFICATION
TYPE OF DRUG ABUSED
MEDICATION TREATMENT
Alcohol
  • Anxiolytics
  • Anticonvulsants
  • Multivltamin supplements
Depressants
  • Anticonvulsants
  • Anxiolytics
Stimulants
  • Anxiolytics
  • Antihypertensives
Narcotics
  • Narcotic antagonists
  • Methadone
Hallucinogens and cannabinols
  • Anxiolytics (infrequently)

FAMILY CARE

Dementia
DSM-IV CATEGORIES
290.xx Dementia of the Alzheimer's type, with early onset
290.10 Dementia of the Alzheimer's type, uncomplicated
290.11 Dementia of the Alzheimer's type, with delirium
290.12 Dementia of the Alzheimer's type, with delusions
290.13 Dementia of the Alzheimer's type, with depressed mood
290.xx Dementia of the Alzheimer's type, with late onset
290.0 Dementia of the Alzheimer's type, uncomplicated
290.3 Dementia of the Alzheimer's type, with delirium
290.20 Dementia of the Alzheimer's type, with delusions
290.21 Dementia of the Alzheimer's type, with depressed mood
290.xx Vascular dementia
290.40 Vascular dementia, uncomplicated
290.41 Vascular dementia, with delirium
290.42 Vascular dementia, with delusions
290.43 Vascular dementia, with depressed mood
294.9 Dementia due to H IV disease
294.1 Dementia due to head trauma
294.1 Dementia due to Parkinson's disease
294.1 Dementia due to Huntington's disease
290.10 Dementia due to Pick's disease
290.10 Dementia due to Creutzfeldt-Jakob disease
294.1 Dementia due to ... [indicate the general medical condition not listed above]
__._ Substance-induced persisting dementia (refer to substance-related disorders for substance-specific codes)
__._ Dementia due to multiple etiologies
294.8 Dementia NOS

A dementia disorder is manifested by multiple cognitive deficits. such as impaired memory, aphasia (loss of speech, writing ability or language comprehension due to disease of the brain such as Alzheimer's Disease [AD] or cerebrovascular disease), apraxia (loss of ability to carry out purposeful movements in the absence of motor or sensory impairment), agnosia (loss of ability to recognize objects despite intact sensory functioning), and a disturbance in occupational or social functioning. These defects can occur as a direct result of a medical problem, the effects of a substance, or a combination of causes, such as AD and cerebrovascular disease. Memory impairment may be first noticed as losing or misplacing persona] items, such as keys and jewelry: forgetting things, such as food that is cooking; and becoming lost in ones own neighborhood. As the memory impairment worsens, the person may forget his name, his birthday, and the names of family members. The ability to comprehend speech or written language becomes compromised. In advanced stages of dementia, the person may become mute or develop a speech pattern characterized by echolalia (repetition of another person's words or phrases) or palilalia (repeating words or sounds over and over). Difficulty performing motor activities, such as combing hair, brushing teeth, and writing name, becomes pronounced.

Disturbances in executive functioning are seen in the loss or the ability to think abstractly. The person with dementia has difficulty performing tasks and begins to avoid situations in which new information must be processed. There is also an inability to plan, sequence, and discontinue complex behaviors. People with dementia become spatially disoriented, demonstrate poor judgment, and have limited or no insight. They tend to overestimate their own abilities and the activities that they can participate in and accomplish. Often there is a disturbance of gait that precipitates falls. Some people manifest anxiety, depression, or sleep disturbances, and others have disinhibited behavior, such as making inappropriate comments, ignoring social behavior, and neglecting personal grooming. Suicidal behavior can occur in the early stage of the disorder, when the person is more cognitively capable of carrying out the suicide plan. People with dementia are extremely susceptible to both physical and psychosocial stressors, which exacerbate their cognitive deficits and other problems.

DEMENTIA OF THE ALZHEIMER TYPE

Clients with dementia of the Alzheimer type manifest a subtle but progressively deteriorating clinical course. Symptoms reveal a loss of intellectual capacities, such as memory, judgment, cognition, orientation, and consistency of mental processes. There are changes in personality, typified by depression, agitation, and confusion. Also evident are behavioral changes, manifested by hyperactivity, wandering, pacing, floccillation (aimless picking at clothing or bed covers), and sleep disturbances. These conditions worsen with time and interfere with personal, social, occupational, and leisure functioning. Eventually, the ability to perform self-care activities is lost. In dementia of the Alzheimer type, cognitive deficits aren't due to disorders of the central nervous system (Parkinson's disease or cerebrovascular disease), systemic conditions (human immunodeficiency virus infection) that are directly linked to dementia, or substance-induced conditions. The disorder affects both women and men. The onset of the early type typically occurs at age 65 or earlier, and the onset of the late type is after age 65. (For further information, see Common Physiologic Causes of Cognitive Disorders.)

Low levels of the neurotransmitter acetylcholine have been found in the brains of clients with dementia. Several other neu-rotransmitters, namely norepinephrine, serotonin, aspartate, gamma-aminobutyric acid, and glutamate, are noted to be at low levels in AD clients. Research indicates that AD is linked to genetic errors on chromosomes 14, 19, and 21. Chromosome 14 is connected to early onset AD, and chromosome 19, to late onset AD. Clients with AD develop neurofibrillary tangles, abnormal protein bundles found in the brain. In addition, there are sphere-shaped protein structures called plaques that are space-occupying lesions. The tangles attack the inside of neurons and the plaques attack the axons and dendrites, thereby causing deterioration of the brain. Researchers have established a link between the gene coding for brain protein found in the plaques and tangles on chromosome 21.

Medications are used to manage the underlying causes of the client's delirium, current health condition, and symptoms associated with an agitated state.

COMMON PHYSIOLOGIC CAUSES OF COGNITIVE DISORDERS

Endocrine dysfuntion


  • Addison's disease
  • Cushings’s disease
  • Diabetic ketoacidosis
  • Hypoglycemia
  • Hypothyroidism
  • Parathyroid disease

Central nervous system disorders


  • Alzheimer’s disease
  • Amyotropyhic Lateral sclerois
  • Brain abscess or tumor
  • Cerebrovascular disease
  • Epilepsy
  • Huntingtons’s disease
  • Meningitis
  • Multiple sclerosis
  • Parkinson’s disease
  • Pick’s disease
  • Septicmia
  • Subdural hematoma
  • Syphilis

Cardiac and vascular disorders


  • Subacute bacterial endocarditis
  • Heartfallure
  • Hjypertension
  • Cerebral atherosclerosis

Nutritional and deficiency states


  • Iron deficiency
  • Penicious anemia
  • Folic acid deficiency
  • Vitamin B (thiamine) deficiency
  • Vitamin B12 (cyanocobalamin) deficiency

Other conditions


  • Acquired immunodeficiency syndrome
  • Liver disease
  • Anoxia
  • Lung disease
  • Kidney disease
  • Pancreatic or hepatic encephalopathy
  • Chronic substance abuse
  • Heavy metal poisonings

The decline in functioning is categorized in three distinct symptom stages: early or amnestic stage, middle or dementia stage, and late or vegetative stage. (See Symptoms of Alzheimer's Disease)

SYMPTOMS OF ALZHEIMER’S DISEASE

Early or Amnestic Stage


  • Anxiety or fear
  • Periods of forgetfulness
  • Irritability, moodiness, or personality changes
  • Increasing periods of confusion
  • Minor dfffticult with actives of daily living (ADLs)
  • Difficulty sleeping

Middle or Dementia Stage


  • Short-term memory loss
  • Unmanageable confusion
  • Decreased concentration and comprehension
  • Difficulty with decision making
  • Motor restlessness (sundown syndrome)
  • Repetitive behaviors
  • Difficulty recognizing people
  • Cycle of depression, blame, and anger
  • Bowel and bladder incontinence

Late or Vegetative Stage


  • Late or Vegetative Stage
  • Long-term memory loss
  • Regression
  • Mutism or verbal communication of only sounds
  • Inability to perform ADLs
  • Difficulty swallowing
  • Weight loss
  • Inability to recognize self or others

COMMUNICATION STRATEGIES

NURSING DIAGNOSIS: RISK FOR TRAUMA
Probable CausesDefining Characteristics
  • Physiological alteration in structure or functioning of the brain
  • Endocrine disorders
  • Neurosensory changes
  • Metabolic disturbance
  • Circulatory disturbance
  • Gait and coordination difficulties
  • Agitated behavior
  • Wandering behavior
  • Disorientation and confusion
  • Inability to use sharp instruments and complicated appliances

Long-Term Goal
The client will not injure self or sustain any accidental injury.

Short-Term Goal #1: The client and family will remove or secure all potential hazards in the home environment.

Interventions and Rationales

Short-Term Goal #2: The client will participate in enjoyable routine activities with close supervision.

Interventions and Rationales

NURSING DIAGNOSIS: SELF-CARE DEFICIT IN BATHING/HYGIENE, DRESSING/GROOMING, FEEDING, OR TOILETING
Probable CausesDefining Characteristics
  • Physiologic problems
  • Attention deficits
  • Memory impairment or confusion
  • Depression or feelings of hopelessness
  • Inability to concentrate on or complete a task
  • Disorientation
  • Difficulty recognizing objects used for care
  • Dirty or inappropriate clothing
  • Poor grooming of hair or nails
  • Uneaten, spoiled, or uncooked food

Long-Term Goal
The client will maintain an appropriate level of participation in self-care as evidenced by performing activities of daily living.

Short-Term Goal #1: The client will demonstrate adequate food and fluid intake.

Interventions and Rationales

Short-Term Goal #2: The client will maximize participation in personal hygiene, toileting, and grooming activities.

Interventions and Rationales

Short-Term Goal #3: The client will maintain a schedule that includes adequate sleep, rest, and activity.

Interventions and Rationales

NURSING DIAGNOSIS: CAREGIVER ROLE STRAIN
Probable CausesDefining Characteristics
  • Unsafe situations involving the client
  • Increased client aggression or agitation
  • Diminishing family support
  • Inability to obtain respite care
  • Dwindling financial resources
  • Verbalized feelings of guilt and of being overwhelmed
  • Anger or depression
  • Lack of patience
  • Possibly neglect or abuse of client
  • Loss of personal and social life

Long-Term Goal
The family will verbalize that they feel supported and can cope with the deterioration and anticipated loss of their family member.

Short-Term Goal #1: The family members will discuss their conflicting or ambivalent feelings about the client.

Interventions and Rationales

Short-Term Goal #2: The family will develop a resource network and become aware of how to access community resources to obtain support and guidance.

Interventions and Rationales

THERAPIES

Medical treatment for dementia is palliative and supportive. Group therapy is based on the premise that care must promote the highest level of functioning possible for the client. The major areas to be addressed are self-care and social and family relationships.

Medical/Biological Interventions
Group Therapy
MEDICATIONS

Medications are administered to assist in managing anxiety, depression, aggression, and paranoid behavior, as well as to replace neurochemicals in the brain.

FAMILY CARE

Amnestic Disorder
DSM-IV CATEGORIES
294.0 Amnesic disorder due to ... [indicate the general medical condition]
__._ Substance-induced persisting amnestic disorder 294.8 Amnestic disorder NOS

People with an amnestic disorder display an inability to learn new information or the inability to recall already learned information and past events. This memory problem negatively influences the person's social and occupational functioning in that spontaneous recall is severely impaired. Some people with an amnestic disorder may remember the remote past but not the recent past. The ability to repeat a string of information such as a digit span is not usually impaired. The disorder is not diagnosed if other cognitive deficits, such as aphasia, apraxia, and agnosia are present. People with an amnestic disorder may require closely supervised living accommodations to assure that basic care needs are met. The age of occurrence varies based on the pathophysiologic condition causing the disorder. Examples of causes of amnestic disorder are traumatic brain injury, cerebrovascular events, prolonged substance use, sustained nutritional deficiency, and carbon monoxide poisoning.

Amnesia is typically seen when there is bilateral damage to the temporal lobe of the brain or to other parts of the limbic system. Depending on where the brain damage occurs, clients with amnestic disorder can manifest various symptoms. Memory loss is extensive after a cerebral injury. In some cases, memory improvement occurs within the first 2 years post trauma; with most injuries, memory loss is permanent.

COMMUNICATION STRATEGIES

NURSING DIAGNOSIS: KNOWLEDGE DEFICIT AND POSSIBLE DENIAL OF BASIC NEEDS RELATED TO SEVERE MEMORY IMPAIRMENT
Probable CausesDefining Characteristics
  • Pathophysiologic condition
  • History of prolonged substance use
  • Lack of insight into memory problem
  • Lack of perception of basic needs
  • Underlying fears
  • Refusal of self-care assistance
  • Emotional blandness
  • Agitation
  • Denial of medical problem
Long-Term Goal
The client will verbalize awareness of physiological health problem and acknowledge the need to obtain assistance from the nurse.

Short-Term Goal #1: The client will identify his current health situation.

Interventions and Rationales

Short-Term Goal #2: The client will demonstrate a working relationship with the nurse to meet self-care needs.

Interventions and Rationales

NURSING DIAGNOSIS: SELF-CARE DEFICIT IN BATHING/HYGIENE, DRESSING/GROOMING, FEEDING, ORTOILETING
Probable CausesDefining Characteristics
  • Physiologic problems
  • Memory impairment
  • Disinterest in self and environment
  • Agitation or confusion
  • Inability to concentrate on or complete a task
  • Disorientation
  • Body odor due to failure to bathe
  • Dirty or inappropriate clothing
  • Poor grooming of hair or nails
  • Eating uneaten, spoiled, or uncooked food

Long-Term Goal
The client will maintain an appropriate level of participation in self-care as evidenced by performing activities of daily living.

Short-Term Goal #1: The client will demonstrate adequate food and fluid intake.

Interventions and Rationales

Short-Term Goal #2: The client will maximize participation in personal hygiene, toileting, and grooming activities.

Interventions and Rationales

Short-Term Goal #3: The client will maintain a schedule that includes adequate sleep, rest, and activity.

Interventions and Rationales

THERAPIES

Medical treatment for a client with an amnestic disorder is supportive. Group therapy is based on the premise that care must promote the highest level of functioning possible for the client. The major areas to be addressed in therapy are self-care and sc-cial and family relationships.

Medical/Biological Interventions
Group Therapy
MEDICATIONS

Medications are administered to assist in managing anxiety, depression, aggression, and paranoid behavior, as well as to replace neurochemicals in the brain.

FAMILY CARE