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This publication benefited from the critical review provided by the following experts in the mental health field: Donald F. Klein, M.D., New York State Psychiatric Institute; R. Bruce Lydiard, Ph.D., M.D., Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina; David A. Katerndahl, M.D., Department of Family Practice, University of Texas; James T. Marron, M.D., Department of Family Practice, University of New York; Thomas W. Uhde, M.D., Division of Intramural Research, National Institute of Mental Health; David H. Barlow, Ph.D., Department of Psychology, State University of New York; and Jack D. Maser, Ph.D., Division of Clinical Research, National Institute of Mental Health. The Institute gratefully acknowledges their reviews and comments.